adj.
feeling small and alone while walking the streets of an unfamiliar city, swept along in the commercial bustle of asphalt and neon, dwarfed by impenetrable monoliths looming high overhead, brushed aside by pulses of traffic carrying on their daily business, with nobody willing to look you in the eye except for the posters encrusted on subway walls, each of them pitching at someone other than you.
From wen, an enormously congested city that swells like a cyst + bane, an affliction or poison.